In a world ravaged by a virus infection, turning its victims into the Undead, Alice (Milla Jovovich) continues on her journey to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation reaches new heights, but Alice gets some unexpected help from an old friend who provides her with some valuable information about a safe haven from the undead in Los Angeles. However when they arrive at the city, they discover that it has been overrun by thousands of Undead and soon Alice and her comrades find themselves entangled in a deadly trap.